What Is SS-31? (In Plain English)

SS-31 is a very short peptide — only four building blocks long. Cells have little power plants called mitochondria, and SS-31 sticks to a special fat that lines their inner wall, a bit like patching the lining of a leaky battery. Researchers study whether that patch helps the power plants stay tidy and make energy more cleanly in lab dishes and in mice.

SS-31 10mg — Research Overview

SS-31 (elamipretide, MTP-131) is a synthetic, cell-permeable aromatic-cationic tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH₂, one of the Szeto-Schiller peptide series. The literature associates it with selective binding to cardiolipin in the inner mitochondrial membrane, where it is described as stabilizing cristae architecture and improving electron-transport-chain coupling in isolated mitochondria. Its mitochondrial localization is reported to be membrane-potential independent, distinguishing it from cationic dyes and other targeting motifs.

Primary Research Areas

• Mitochondrial bioenergetics — investigated in isolated mitochondria for cardiolipin binding and ATP-production efficiency
• Oxidative stress — studied in vitro for changes in reactive oxygen species generation at the electron transport chain
• Ischemia-reperfusion models — examined in animal models of cardiac and renal reperfusion injury
• Age-related muscle decline — investigated in aged rodent skeletal muscle for mitochondrial function endpoints
• Primary mitochondrial disease models — referenced in preclinical work on cristae morphology and respiratory-chain assembly

Specifications

• Compound: SS-31 (elamipretide, MTP-131, Szeto-Schiller peptide 31)
• CAS: 736992-21-5
• Molecular formula: C₃₂H₄₉N₉O₅
• Molecular weight: ~639.8 g/mol (free base)
• Presentation: Lyophilized powder, sealed vial
• Quantity: 10 mg per vial
• Storage: Store lyophilized vials cold and protected from light. Reconstituted material is stored refrigerated per standard laboratory practice.

Related Research Peptides

SS-31 sits within the mitochondrial and longevity research area and is often studied alongside other mitochondrial and longevity research compounds. Related catalog listings include MOTS-c 10mg, FOXO4-DRI 10mg, NAD+ 500mg, and Epithalon 10mg.

Why Researchers Source SS-31 from Dissolv Labs

Dissolv Labs is a research-supply company based in Southern California. Orders are picked, packed, and shipped domestically from our SoCal facility, so most U.S. laboratories see short transit times and no international customs delay.

Every vial ships as a complete kit. Each SS-31 vial is paired with its own bacteriostatic water reconstitution vial, so the material arrives ready to prepare in the lab without a separate diluent order. Compounds are supplied lyophilized in sealed, labeled vials with lot identification, and analytical documentation is available on request.

SS-31 — Frequently Asked Questions

What is SS-31 used for?

SS-31 is supplied strictly as a research chemical for in vitro and laboratory research applications. The literature studies it as a cardiolipin-binding mitochondrial-targeted tetrapeptide in bioenergetics, oxidative-stress, and preclinical reperfusion research. It is not for human or veterinary use.

How does SS-31 differ from MOTS-c?

Both are studied in mitochondrial biology, but they act at different levels. SS-31 is a four-residue synthetic peptide that localizes to the inner mitochondrial membrane and binds cardiolipin directly, whereas MOTS-c is a 16-residue mitochondrial-derived peptide associated in the literature with AMPK-linked nuclear signaling. Laboratories comparing structural versus signaling approaches often run both.

Is SS-31 the same as elamipretide?

Yes — SS-31, elamipretide, and MTP-131 refer to the same D-Arg-Dmt-Lys-Phe-NH₂ tetrapeptide, with SS-31 being the original Szeto-Schiller research designation. Publications use the names interchangeably, so literature searches should cover all three terms. Material supplied here is labeled by lot for reference against analytical documentation.

Where can I buy SS-31 10mg research peptide?

SS-31 10mg is available for sale from Dissolv Labs, a Southern California research-supply company. Orders ship domestically from our SoCal facility as a complete kit with a bacteriostatic water vial included. Analytical documentation is available on request for qualified laboratories.

Research Use Only

SS-31 is sold exclusively as a Research Use Only (RUO) chemical. It is not a drug, supplement, cosmetic, or food, and it is not intended for human or veterinary use, ingestion, injection, topical application, or any form of consumption. It is intended solely for licensed laboratory research by qualified professionals. Dissolv Labs makes no medical, therapeutic, or diagnostic claims of any kind. By purchasing, the buyer confirms they are a qualified researcher and accepts full responsibility for lawful handling, use, and disposal.

Bacteriostatic (BAC) water is included free with every order.

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