What Is SS-31? (In Plain English)

SS-31 is a very short peptide — only four building blocks long. Cells have little power plants called mitochondria, and SS-31 sticks to a special fat that lines their inner wall, a bit like patching the lining of a leaky battery. Researchers study whether that patch helps the power plants stay tidy and make energy more cleanly in lab dishes and in mice.

SS-31 10mg — Research Overview

SS-31 (elamipretide, MTP-131) is a synthetic, cell-permeable aromatic-cationic tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH₂, one of the Szeto-Schiller peptide series. The literature associates it with selective binding to cardiolipin in the inner mitochondrial membrane, where it is described as stabilizing cristae architecture and improving electron-transport-chain coupling in isolated mitochondria. Its mitochondrial localization is reported to be membrane-potential independent, distinguishing it from cationic dyes and other targeting motifs.

Primary Research Areas

• Mitochondrial bioenergetics — investigated in isolated mitochondria for cardiolipin binding and ATP-production efficiency
• Oxidative stress — studied in vitro for changes in reactive oxygen species generation at the electron transport chain
• Ischemia-reperfusion models — examined in animal models of cardiac and renal reperfusion injury
• Age-related muscle decline — investigated in aged rodent skeletal muscle for mitochondrial function endpoints
• Primary mitochondrial disease models — referenced in preclinical work on cristae morphology and respiratory-chain assembly

Specifications

• Compound: SS-31 (elamipretide, MTP-131, Szeto-Schiller peptide 31)
• CAS: 736992-21-5
• Molecular formula: C₃₂H₄₉N₉O₅
• Molecular weight: ~639.8 g/mol (free base)
• Presentation: Lyophilized powder, sealed vial
• Quantity: 10 mg per vial
• Storage: Store lyophilized vials cold and protected from light. Reconstituted material is stored refrigerated per standard laboratory practice.

Related Research Peptides

SS-31 sits within the mitochondrial and longevity research area and is often studied alongside other mitochondrial-derived peptides. Related catalog listings include MOTS-c 10mg, Humanin 10 mg, NAD+ 500mg, and Epithalon 10mg.

Why Researchers Source SS-31 from Dissolv Labs

Dissolv Labs is a research-supply company based in Southern California. Orders are picked, packed, and shipped domestically from our SoCal facility, so most U.S. laboratories see short transit times and no international customs delay.

Every vial ships as a complete kit. Each SS-31 vial is paired with its own bacteriostatic water reconstitution vial, so the material arrives ready to prepare in the lab without a separate diluent order. Compounds are supplied lyophilized in sealed, labeled vials with lot identification, and analytical documentation is available on request.

SS-31 — Frequently Asked Questions

What is SS-31 used for?

SS-31 is supplied strictly as a research chemical for in vitro and laboratory research applications. The literature studies it as a cardiolipin-binding mitochondrial-targeted tetrapeptide in bioenergetics, oxidative-stress, and preclinical reperfusion research. It is not for human or veterinary use.

How does SS-31 differ from MOTS-c?

Both are studied in mitochondrial biology, but they act at different levels. SS-31 is a four-residue synthetic peptide that localizes to the inner mitochondrial membrane and binds cardiolipin directly, whereas MOTS-c is a 16-residue mitochondrial-derived peptide associated in the literature with AMPK-linked nuclear signaling. Laboratories comparing structural versus signaling approaches often run both.

Is SS-31 the same as elamipretide?

Yes — SS-31, elamipretide, and MTP-131 refer to the same D-Arg-Dmt-Lys-Phe-NH₂ tetrapeptide, with SS-31 being the original Szeto-Schiller research designation. Publications use the names interchangeably, so literature searches should cover all three terms. Material supplied here is labeled by lot for reference against analytical documentation.

Where can I buy SS-31 10mg research peptide?

SS-31 10mg is available for sale from Dissolv Labs, a Southern California research-supply company. Orders ship domestically from our SoCal facility as a complete kit with a bacteriostatic water vial included. Analytical documentation is available on request for qualified laboratories.

Research Use Only

SS-31 is sold exclusively as a Research Use Only (RUO) chemical. It is not a drug, supplement, cosmetic, or food, and it is not intended for human or veterinary use, ingestion, injection, topical application, or any form of consumption. It is intended solely for licensed laboratory research by qualified professionals. Dissolv Labs makes no medical, therapeutic, or diagnostic claims of any kind. By purchasing, the buyer confirms they are a qualified researcher and accepts full responsibility for lawful handling, use, and disposal.

Bacteriostatic (BAC) water is included free with every order.

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• Form: Lyophilized (freeze-dried) powder, sealed vial
• Appearance: White to off-white
• Purity: ≥99%, verified by HPLC
• Identity: Confirmed by mass spectrometry
• Testing: Independent third-party laboratory, every batch
• Documentation: Batch-specific COA available on request

Exact quantity and concentration are listed in the product title and variant options above. The figures above are release specifications — the measured result for your particular lot is stated on its Certificate of Analysis.

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Every batch is tested before release. Testing covers four checks: identity by mass spectrometry, purity by HPLC against a ≥99% release threshold, content verification against the labelled mass, and batch release tied to a specific lot number.

To request the Certificate of Analysis for your vial, email us with your order number or the lot number printed on the label. We do not gate documentation behind a form or a purchase.

New to reading a COA? Our plain-English guide decodes every line, and the full process is documented on our Quality & Testing page.

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Lyophilized peptides are relatively stable during transit. Arriving at room temperature is not cause for concern — the cold pack is a margin of safety rather than a pass/fail condition.

Sealed vials of lyophilized material are typically stored refrigerated or frozen and protected from light. Handling protocols for a specific compound are determined by the researcher and their institution; we supply the material and its documentation.

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Orders placed before the daily cut-off are dispatched the same business day from Southern California in insulated packaging with ice packs. Tracking is issued at dispatch.

If a shipment arrives damaged, if vial contents appear inconsistent with the specification, or if the lot number on your vial does not match the certificate we provide, contact us and we will resolve it.

Because these are temperature-sensitive laboratory materials, opened vials cannot be returned to stock.

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