Description
What Is FOXO4-DRI? (In Plain English)
FOXO4-DRI is a lab-built peptide made as a mirror image of a natural one, so enzymes have a hard time chewing it up. Old, worn-out cells sometimes refuse to clear out, like a jammed door that will not close; this peptide is designed to break up the protein handshake holding that door open. Researchers use it in cell cultures and in mice to see which cells go and which stay.
FOXO4-DRI 10mg — Research Overview
FOXO4-DRI is a D-retro-inverso peptide built from D-amino acids in reversed sequence order, a design that preserves side-chain topology while sharply increasing protease resistance. The literature describes it as a competitive disruptor of the FOXO4–p53 protein-protein interaction, promoting nuclear exclusion of p53 in senescent cells and selective apoptosis in that population. It was introduced in senolytic work by Baar and colleagues and is now used broadly as a tool compound in senescence research.
Primary Research Areas
- Senolytics — investigated in vitro for selective clearance of senescent fibroblasts while sparing proliferating cells
- FOXO4–p53 interaction — used as a tool reagent in co-immunoprecipitation and nuclear-localisation assays
- Senescence-associated secretory phenotype — studied for changes in SASP cytokine profiles in aged cell cultures
- Aged rodent models — referenced in the literature for tissue-level markers of senescent burden
- Peptide chemistry — examined as a worked example of D-retro-inverso design and its effect on peptide half-life
Specifications
- Compound: FOXO4-DRI, FOXO4 D-Retro-Inverso peptide, FOXO4-p53 interfering peptide
- CAS: Not assigned
- Presentation: Lyophilized powder, sealed vial
- Quantity: 10mg per vial
- Storage: Store lyophilized vials cold and protected from light. Reconstituted material is stored refrigerated per standard laboratory practice.
Related Research Peptides
Senescence laboratories generally hold FOXO4-DRI alongside other longevity-pathway compounds, notably Epithalon 10mg for telomere work and SS-31 10mg for mitochondrial models. Groups studying p53 biology or NAD-dependent repair pathways also stock PNC-27 5mg and NAD+ 500mg.
Why Researchers Source FOXO4-DRI from Dissolv Labs
Dissolv Labs is a research-supply company based in Southern California. Orders are picked, packed, and shipped domestically from our SoCal facility, so most U.S. laboratories see short transit times and no international customs delay.
Every vial ships as a complete kit. Each FOXO4-DRI vial is paired with its own bacteriostatic water reconstitution vial, so the material arrives ready to prepare in the lab without a separate diluent order. Compounds are supplied lyophilized in sealed, labeled vials with lot identification, and analytical documentation is available on request.
FOXO4-DRI 10mg — Frequently Asked Questions
What is FOXO4-DRI used for?
FOXO4-DRI is supplied strictly as a research chemical for in vitro and laboratory research applications. The literature investigates it as a senolytic tool compound that interferes with the FOXO4–p53 interaction in senescent cell populations. It is not for human or veterinary use.
What does the “DRI” in FOXO4-DRI mean?
DRI stands for D-retro-inverso. The sequence is reversed and built from D-amino acids instead of the usual L-form, which leaves the arrangement of side chains close to the original while making the peptide much harder for proteases to cleave. This is why the DRI variant, rather than the plain L-peptide, is the version used in most published senescence assays.
How is FOXO4-DRI 10mg stored and reconstituted?
The vial contains 10mg of lyophilized FOXO4-DRI, sealed and lot-labeled, and ships with a matched bacteriostatic water reconstitution vial. Lyophilized material is kept cold and out of light; once reconstituted it is refrigerated and typically aliquoted to avoid repeated freeze-thaw. Additional BAC Water 3ml is available separately.
Where can I buy FOXO4-DRI research peptide?
FOXO4-DRI 10mg is for sale directly from Dissolv Labs, a Southern California research-supply company. Orders ship domestically from our SoCal facility as a complete kit including the reconstitution vial, with analytical documentation available on request to qualified laboratory buyers.
Research Use Only
FOXO4-DRI is sold exclusively as a Research Use Only (RUO) chemical. It is not a drug, supplement, cosmetic, or food, and it is not intended for human or veterinary use, ingestion, injection, topical application, or any form of consumption. It is intended solely for licensed laboratory research by qualified professionals. Dissolv Labs makes no medical, therapeutic, or diagnostic claims of any kind. By purchasing, the buyer confirms they are a qualified researcher and accepts full responsibility for lawful handling, use, and disposal.
Bacteriostatic (BAC) water is included free with every order.
Specifications
- Form: Lyophilized (freeze-dried) powder, sealed vial
- Appearance: White to off-white
- Purity: ≥99%, verified by HPLC
- Identity: Confirmed by mass spectrometry
- Testing: Independent third-party laboratory, every batch
- Documentation: Batch-specific COA available on request
Exact quantity and concentration are listed in the product title and variant options above. The figures above are release specifications — the measured result for your particular lot is stated on its Certificate of Analysis.
Documentation & Testing
Every batch is tested before release. Testing covers four checks: identity by mass spectrometry, purity by HPLC against a ≥99% release threshold, content verification against the labelled mass, and batch release tied to a specific lot number.
To request the Certificate of Analysis for your vial, email us with your order number or the lot number printed on the label. We do not gate documentation behind a form or a purchase.
New to reading a COA? Our plain-English guide decodes every line, and the full process is documented on our Quality & Testing page.
Handling & Storage
Lyophilized peptides are relatively stable during transit. Arriving at room temperature is not cause for concern — the cold pack is a margin of safety rather than a pass/fail condition.
Sealed vials of lyophilized material are typically stored refrigerated or frozen and protected from light. Handling protocols for a specific compound are determined by the researcher and their institution; we supply the material and its documentation.
Shipping & Returns
Orders placed before the daily cut-off are dispatched the same business day from Southern California in insulated packaging with ice packs. Tracking is issued at dispatch.
If a shipment arrives damaged, if vial contents appear inconsistent with the specification, or if the lot number on your vial does not match the certificate we provide, contact us and we will resolve it.
Because these are temperature-sensitive laboratory materials, opened vials cannot be returned to stock.
Questions
Straight answers about documentation, shipping, and what Research Use Only means.