Description
MOTS-c — Research Peptide
MOTS-c is a 16-amino-acid synthetic peptide referenced in scientific literature as a mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA.
Purity: ≥99% (HPLC-MS verified)
Format: 10mg lyophilized vial, sealed amber glass
Designation: Research use only — not intended for human or veterinary use
Compound Overview
MOTS-c (Mitochondrial Open Reading frame of the Twelve S rRNA-c) is a short peptide encoded within the mitochondrial genome rather than the nuclear genome — placing it within the small but rapidly expanding family of mitochondrial-derived peptides.
Within the published literature, MOTS-c is most commonly studied within AMPK pathway research, mitochondrial-nuclear signaling research, and metabolic homeostasis research models. It is frequently positioned alongside Humanin and the SHLP family of mitochondrial-derived peptides.
Research Context
MOTS-c has been investigated in published research literature and is commonly referenced in laboratory work involving:
- Mitochondrial-derived peptide (MDP) biology
- AMPK (AMP-activated protein kinase) pathway research
- Mitochondrial-nuclear retrograde signaling research
- Metabolic homeostasis and glucose metabolism research models
- Exercise physiology and muscle bioenergetics research
- Aging biology and longevity research domains
- Comparative mitochondrial peptide research
Scientific Classification
| Compound name | MOTS-c |
| Molecular class | Synthetic peptide (16 amino acids) |
| Functional category | Mitochondrial-derived peptide (MDP); AMPK pathway research compound |
| Peptide family | Mitochondrial-derived peptide family (with Humanin and SHLP-1 through SHLP-6) |
| Research domains | Mitochondrial biology, AMPK signaling, metabolic homeostasis, exercise physiology research, mitochondrial-nuclear signaling, aging biology |
| Adjacent compounds | Humanin, SHLP peptides, SS-31 (Elamipretide), NAD+, NMN, Epitalon, Spermidine |
Analytical & Quality Standards
Every MOTS-c lot supplied by DISSOLV LABS undergoes a structured analytical workflow designed to confirm identity, purity, and batch consistency before release.
- Purity verification by reversed-phase high-performance liquid chromatography (RP-HPLC)
- Identity confirmation by mass spectrometry (HPLC-MS)
- Residual solvent and moisture screening to documented thresholds
- Batch-to-batch consistency recorded on a per-lot Certificate of Analysis (COA)
- Third-party verification available upon institutional request
- Sterile lyophilization under inert conditions to preserve peptide integrity
Technical Specifications
| Format | 10mg lyophilized vial |
| Appearance | Uniform, free-flowing white lyophilized solid |
| Packaging | Sealed amber glass vial, crimped seal |
| Catalog identifier | DSL-MOTSC-0010 |
| Purity | ≥99% (HPLC-MS verified) |
| Recommended storage | −20 °C, protected from light and moisture |
| Reconstitution | Sterile or bacteriostatic solvent (laboratory protocol only) |
| Stability | Stable under recommended storage conditions; refer to lot COA |
| Handling | Restricted to qualified research personnel |
Frequently Asked Questions
What is a mitochondrial-derived peptide?
Mitochondrial-derived peptides (MDPs) are short peptides encoded within the mitochondrial genome rather than the nuclear genome. The family includes MOTS-c, Humanin, and the SHLP-1 through SHLP-6 peptides.
How does MOTS-c relate to NAD+ and NMN?
MOTS-c and NAD+/NMN are studied in overlapping research domains. MOTS-c is a mitochondrial-derived peptide; NAD+ is a pyridine nucleotide coenzyme. They represent distinct molecular classes commonly investigated side by side in mitochondrial bioenergetics research.
What purity standard does DISSOLV LABS supply?
DISSOLV LABS supplies MOTS-c at ≥99% purity, verified by reversed-phase HPLC and confirmed by mass spectrometry (HPLC-MS). Each lot is accompanied by a Certificate of Analysis.
What analytical testing is performed on each lot?
Each MOTS-c lot is subjected to RP-HPLC purity analysis, HPLC-MS identity confirmation, residual solvent and moisture screening, and batch-consistency documentation. Third-party analytical verification is available upon institutional request.
How should MOTS-c be stored?
Recommended storage is −20 °C, protected from light and moisture, in the original sealed vial. Refer to the lot-specific Certificate of Analysis for stability data.
How is MOTS-c reconstituted for laboratory work?
MOTS-c is typically reconstituted with sterile or bacteriostatic solvent in accordance with the receiving laboratory's internal protocols. Reconstitution methodology is the responsibility of the qualified research professional.
Is MOTS-c research use only?
Yes. MOTS-c supplied by DISSOLV LABS is strictly for laboratory research use only. It is not intended for human or veterinary use, and is not intended to diagnose, treat, cure, or prevent any disease.
Is a Certificate of Analysis (COA) available?
Yes. Every lot is shipped with a lot-specific Certificate of Analysis documenting purity, identity, and analytical methodology. COAs are available to verified research accounts on request.
Who should handle MOTS-c?
MOTS-c is intended exclusively for handling by qualified laboratory research professionals operating within appropriate research facilities. It is not for sale to or use by the general public.
Related Research Compounds
- Humanin
- SHLP peptides
- SS-31 (Elamipretide)
- NAD+
- NMN
- Epitalon
- Spermidine
Compliance
For laboratory research use only. This product is not intended for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease. Sale and distribution are restricted to qualified laboratory research professionals operating within appropriate research environments. The purchaser assumes full responsibility for safe handling, storage, and disposal in accordance with applicable institutional, local, and federal guidelines.
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