Description
What Is MOTS-c 10mg? (In Plain English)
MOTS-c is a short chain of 16 amino acids that a cell's mitochondria write themselves, like a small factory sending a memo up to head office. Most peptides come from the main blueprint in the nucleus, so this one takes an unusual route. Researchers keep it in the freezer and add it to cells or mice to watch what that memo changes.
MOTS-c 10mg — Research Overview
MOTS-c is a mitochondrial-derived peptide translated from a short open reading frame within the mitochondrial 12S rRNA gene, giving the 16-residue sequence MRWQEMGYIFYPRKLR. In the literature it is linked to AMPK pathway activation and to interference with the folate–methionine one-carbon cycle, with downstream effects on purine biosynthesis intermediates reported in vitro. Under metabolic stress it has been described translocating to the nucleus, placing it among the small group of peptides studied as mitochondrial-to-nuclear retrograde signals.
Primary Research Areas
- Cellular energy sensing — AMPK phosphorylation studied in cultured myotubes and hepatocytes
- One-carbon metabolism — folate cycle and AICAR-related intermediates examined in vitro
- Rodent metabolic models — investigated for glucose-handling and adiposity endpoints in mice
- Mitochondrial genomics — used as a model system for mtDNA-encoded short open reading frames
- Skeletal muscle adaptation — referenced in exercise-physiology literature as an exercise-responsive peptide
Specifications
- Compound: MOTS-c; mitochondrial ORF of the 12S rRNA type-c peptide
- CAS: 1627580-64-6
- Presentation: Lyophilized powder, sealed vial
- Quantity: 10mg per vial
- Storage: Store lyophilized vials cold and protected from light. Reconstituted material is stored refrigerated per standard laboratory practice.
Related Research Peptides
Groups working on mitochondrial peptides typically pair MOTS-c 10mg with SS-31 10mg and Humanin 10 mg for comparative mitochondrial-function assays. Metabolic laboratories also stock NAD+ 500mg and 5-Amino-1MQ 10mg when profiling NAD-salvage and energy-expenditure pathways in parallel.
Why Researchers Source MOTS-c from Dissolv Labs
Dissolv Labs is a research-supply company based in Southern California. Orders are picked, packed, and shipped domestically from our SoCal facility, so most U.S. laboratories see short transit times and no international customs delay.
Every vial ships as a complete kit. Each MOTS-c vial is paired with its own bacteriostatic water reconstitution vial, so the material arrives ready to prepare in the lab without a separate diluent order. Compounds are supplied lyophilized in sealed, labeled vials with lot identification, and analytical documentation is available on request.
MOTS-c 10mg — Frequently Asked Questions
What is MOTS-c used for?
MOTS-c is supplied strictly as a research chemical for in vitro and laboratory research applications. Published work examines it as an mtDNA-encoded peptide influencing AMPK and folate-cycle signalling in cell culture and rodent models. It is not for human or veterinary use.
MOTS-c vs Humanin — how are they compared in the literature?
Both are mitochondrial-derived peptides, but humanin is encoded in the 16S rRNA region and is studied largely around cytoprotection and apoptosis signalling. MOTS-c is encoded in the 12S rRNA region and is examined mainly through metabolic and AMPK-linked endpoints. Comparative studies often assay them together to separate the two signalling profiles.
How much material is in a MOTS-c 10mg vial?
Each sealed vial contains 10mg of lyophilized MOTS-c with lot identification printed on the label. The kit includes a matched bacteriostatic water vial for bench reconstitution, and larger volumes are available as BAC Water 10ml. Unopened vials are held cold and protected from light.
Where can I buy MOTS-c 10mg for sale online?
MOTS-c 10mg ships from Dissolv Labs in Southern California, packed and dispatched domestically so U.S. laboratories avoid customs delay. Every order includes the reconstitution vial, and analytical documentation can be requested for any lot. Sales are restricted to qualified researchers for Research Use Only applications.
Research Use Only
MOTS-c is sold exclusively as a Research Use Only (RUO) chemical. It is not a drug, supplement, cosmetic, or food, and it is not intended for human or veterinary use, ingestion, injection, topical application, or any form of consumption. It is intended solely for licensed laboratory research by qualified professionals. Dissolv Labs makes no medical, therapeutic, or diagnostic claims of any kind. By purchasing, the buyer confirms they are a qualified researcher and accepts full responsibility for lawful handling, use, and disposal.
Bacteriostatic (BAC) water is included free with every order.
Specifications
- Form: Lyophilized (freeze-dried) powder, sealed vial
- Appearance: White to off-white
- Purity: ≥99%, verified by HPLC
- Identity: Confirmed by mass spectrometry
- Testing: Independent third-party laboratory, every batch
- Documentation: Batch-specific COA available on request
Exact quantity and concentration are listed in the product title and variant options above. The figures above are release specifications — the measured result for your particular lot is stated on its Certificate of Analysis.
Documentation & Testing
Every batch is tested before release. Testing covers four checks: identity by mass spectrometry, purity by HPLC against a ≥99% release threshold, content verification against the labelled mass, and batch release tied to a specific lot number.
To request the Certificate of Analysis for your vial, email us with your order number or the lot number printed on the label. We do not gate documentation behind a form or a purchase.
New to reading a COA? Our plain-English guide decodes every line, and the full process is documented on our Quality & Testing page.
Handling & Storage
Lyophilized peptides are relatively stable during transit. Arriving at room temperature is not cause for concern — the cold pack is a margin of safety rather than a pass/fail condition.
Sealed vials of lyophilized material are typically stored refrigerated or frozen and protected from light. Handling protocols for a specific compound are determined by the researcher and their institution; we supply the material and its documentation.
Shipping & Returns
Orders placed before the daily cut-off are dispatched the same business day from Southern California in insulated packaging with ice packs. Tracking is issued at dispatch.
If a shipment arrives damaged, if vial contents appear inconsistent with the specification, or if the lot number on your vial does not match the certificate we provide, contact us and we will resolve it.
Because these are temperature-sensitive laboratory materials, opened vials cannot be returned to stock.
Questions
Straight answers about documentation, shipping, and what Research Use Only means.