Description
What Is PNC-27? (In Plain English)
PNC-27 is two short peptides joined into one molecule. One half is copied from a natural protein that cells use as a safety inspector, and the other half acts like an anchor that helps the molecule wedge into a cell's outer wall. Researchers add it to dishes of cultured cells to see which cells it anchors into and what happens after that.
PNC-27 — Research Overview
PNC-27 is a chimeric peptide combining residues 12-26 of the p53 protein — the HDM-2 binding domain — with a membrane-residency sequence derived from the antennapedia homeodomain (penetratin). The literature associates it with binding to HDM-2 expressed at the plasma membrane of transformed cells, followed by transmembrane pore formation and membrane leakage in vitro. The mechanistic model is specific to a single research group's body of work and remains debated in the wider field.
Primary Research Areas
- Cancer cell line studies — investigated in vitro for differential membrane effects between transformed and non-transformed cultures.
- HDM-2 / MDM2 biology — studied as a probe for membrane-localised HDM-2 expression.
- Membrane pore formation — examined in artificial lipid bilayer and liposome assays.
- p53 pathway research — referenced in the literature on p53-derived peptide fragments and protein–protein interaction inhibition.
- Cell-penetrating peptide design — used as a reference construct for penetratin-fused cargo peptides.
Specifications
- Compound: PNC-27 (p53 12-26 / penetratin membrane-residency chimeric peptide)
- CAS: Not assigned
- Presentation: Lyophilized powder, sealed vial
- Quantity: 5 mg per vial
- Storage: Store lyophilized vials cold and protected from light. Reconstituted material is stored refrigerated per standard laboratory practice.
Related Research Peptides
Laboratories working with PNC-27 5mg frequently also stock FOXO4-DRI 10mg, another p53-interacting research peptide, and Epithalon 10mg. MOTS-c 10mg and SS-31 10mg are common companions in cellular and mitochondrial research panels.
Why Researchers Source PNC-27 from Dissolv Labs
Dissolv Labs is a research-supply company based in Southern California. Orders are picked, packed, and shipped domestically from our SoCal facility, so most U.S. laboratories see short transit times and no international customs delay.
Every vial ships as a complete kit. Each PNC-27 vial is paired with its own bacteriostatic water reconstitution vial, so the material arrives ready to prepare in the lab without a separate diluent order. Compounds are supplied lyophilized in sealed, labeled vials with lot identification, and analytical documentation is available on request.
PNC-27 — Frequently Asked Questions
What is PNC-27 used for?
PNC-27 is supplied strictly as a research chemical for in vitro and laboratory research applications. The literature investigates it as a p53-derived membrane-residency peptide in cultured cell lines and lipid bilayer assays. It is not for human or veterinary use.
How does PNC-27 differ from FOXO4-DRI?
Both peptides intersect with p53 biology but through different routes. FOXO4-DRI is a retro-inverso peptide studied for disrupting the FOXO4-p53 interaction inside senescent cells, while PNC-27 carries a p53 fragment to the cell membrane and is studied for membrane-level effects. They are typically used as distinct probes rather than substitutes.
How is PNC-27 handled in the laboratory?
PNC-27 ships as a 5 mg lyophilized powder in a sealed, labeled vial with lot identification. It is a relatively long and hydrophobic peptide, so laboratories commonly note solubility conditions before preparation; lyophilized material is stored cold and dark and reconstituted solution is refrigerated per standard laboratory practice. Each kit includes a bacteriostatic water reconstitution vial.
Where can I buy PNC-27 research peptide?
PNC-27 5mg is available for sale from Dissolv Labs, a Southern California research-supply company shipping domestically across the United States. Every order arrives as a complete kit with matched reconstitution vial and analytical documentation on request.
Research Use Only
PNC-27 is sold exclusively as a Research Use Only (RUO) chemical. It is not a drug, supplement, cosmetic, or food, and it is not intended for human or veterinary use, ingestion, injection, topical application, or any form of consumption. It is intended solely for licensed laboratory research by qualified professionals. Dissolv Labs makes no medical, therapeutic, or diagnostic claims of any kind. By purchasing, the buyer confirms they are a qualified researcher and accepts full responsibility for lawful handling, use, and disposal.
Bacteriostatic (BAC) water is included free with every order.
Specifications
- Form: Lyophilized (freeze-dried) powder, sealed vial
- Appearance: White to off-white
- Purity: ≥99%, verified by HPLC
- Identity: Confirmed by mass spectrometry
- Testing: Independent third-party laboratory, every batch
- Documentation: Batch-specific COA available on request
Exact quantity and concentration are listed in the product title and variant options above. The figures above are release specifications — the measured result for your particular lot is stated on its Certificate of Analysis.
Documentation & Testing
Every batch is tested before release. Testing covers four checks: identity by mass spectrometry, purity by HPLC against a ≥99% release threshold, content verification against the labelled mass, and batch release tied to a specific lot number.
To request the Certificate of Analysis for your vial, email us with your order number or the lot number printed on the label. We do not gate documentation behind a form or a purchase.
New to reading a COA? Our plain-English guide decodes every line, and the full process is documented on our Quality & Testing page.
Handling & Storage
Lyophilized peptides are relatively stable during transit. Arriving at room temperature is not cause for concern — the cold pack is a margin of safety rather than a pass/fail condition.
Sealed vials of lyophilized material are typically stored refrigerated or frozen and protected from light. Handling protocols for a specific compound are determined by the researcher and their institution; we supply the material and its documentation.
Shipping & Returns
Orders placed before the daily cut-off are dispatched the same business day from Southern California in insulated packaging with ice packs. Tracking is issued at dispatch.
If a shipment arrives damaged, if vial contents appear inconsistent with the specification, or if the lot number on your vial does not match the certificate we provide, contact us and we will resolve it.
Because these are temperature-sensitive laboratory materials, opened vials cannot be returned to stock.
Questions
Straight answers about documentation, shipping, and what Research Use Only means.