Description
NAD+ — Research Coenzyme
NAD+ (Nicotinamide Adenine Dinucleotide) is a naturally occurring coenzyme referenced in an extensive body of scientific literature spanning cellular metabolism, mitochondrial function, sirtuin pathway research, and redox biology. DISSOLV LABS supplies NAD+ in 500 mg and 1000 mg lyophilized vial formats as a high-purity analytical reference compound for qualified laboratory research professionals.
Purity: ≥99% (HPLC-MS verified)
Formats: 500 mg lyophilized vial · 1000 mg lyophilized vial
Designation: Research use only — not intended for human or veterinary use
Compound Overview
NAD+ is a dinucleotide composed of two nucleotides joined through their phosphate groups — one bearing an adenine nucleobase, the other bearing nicotinamide. It is classified as a pyridine nucleotide coenzyme and is central to a wide range of enzymatic reactions referenced in published biochemistry, cellular metabolism, and aging biology research literature.
Within the published literature, NAD+ is positioned alongside its biosynthetic precursors — NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) — and is among the most extensively cited reference compounds in modern longevity, mitochondrial, and sirtuin pathway research.
Research Context
NAD+ has been investigated in an extensive body of preclinical and clinical research and is commonly referenced in laboratory work involving:
- Cellular metabolism and energy biochemistry research
- Mitochondrial function and bioenergetics research
- Sirtuin enzyme pathway research (SIRT1–SIRT7)
- PARP enzyme activity and DNA-repair biology research
- Redox biology and NAD+/NADH ratio research
- Aging biology and longevity research domains
- Comparative NAD+ precursor research (NMN, NR)
- CD38 and NAD+ metabolism research
Scientific Classification
| Compound name | NAD+ (Nicotinamide Adenine Dinucleotide) |
| Molecular class | Pyridine nucleotide coenzyme (dinucleotide) |
| Structural composition | Adenine nucleotide + nicotinamide nucleotide, linked via phosphate groups |
| Functional category | Redox coenzyme; substrate for sirtuin and PARP enzyme families |
| Compound family | NAD+ metabolome research compounds |
| Research domains | Cellular metabolism, mitochondrial biology, sirtuin pathway research, DNA-repair biology, redox biology, aging biology, longevity research |
| Adjacent compounds | NMN, NR, NADH, Niacinamide, Resveratrol, Pterostilbene, Epitalon, Spermidine |
Analytical & Quality Standards
Every NAD+ lot supplied by DISSOLV LABS — across both 500 mg and 1000 mg vial formats — undergoes a structured analytical workflow designed to confirm identity, purity, and batch consistency before release.
- Purity verification by reversed-phase high-performance liquid chromatography (RP-HPLC)
- Identity confirmation by mass spectrometry (HPLC-MS)
- UV-Vis spectroscopic verification at characteristic 260 nm absorbance
- Residual solvent and moisture screening to documented thresholds
- Batch-to-batch consistency recorded on a per-lot Certificate of Analysis (COA)
- Third-party verification available upon institutional request
- Sterile lyophilization under inert conditions to preserve coenzyme integrity
Technical Specifications
| Available formats | 500 mg lyophilized vial · 1000 mg lyophilized vial |
| Appearance | Uniform, free-flowing white to off-white lyophilized solid |
| Packaging | Sealed amber glass vial, crimped seal |
| Catalog identifiers | DSL-NAD-500 (500 mg) · DSL-NAD-1000 (1000 mg) |
| Purity | ≥99% (HPLC-MS verified) |
| Molecular formula | C₂₁H₂₇N₇O₁₄P₂ |
| Molecular weight | 663.43 g/mol |
| Recommended storage | −20 °C, protected from light and moisture |
| Reconstitution | Sterile or bacteriostatic solvent (laboratory protocol only) |
| Stability | Stable under recommended storage conditions; refer to lot COA |
| Handling | Restricted to qualified research personnel |
Frequently Asked Questions
What is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is a naturally occurring pyridine nucleotide coenzyme referenced in scientific literature as central to cellular metabolism, mitochondrial function, and sirtuin pathway biology. It is a dinucleotide composed of an adenine nucleotide and a nicotinamide nucleotide joined via phosphate groups. Supplied by DISSOLV LABS as an analytical reference compound for laboratory research use only.
What vial sizes are available?
DISSOLV LABS supplies NAD+ in two lyophilized vial formats: 500 mg (catalog DSL-NAD-500) and 1000 mg (catalog DSL-NAD-1000). Both formats are produced from the same ≥99% purity reference material and accompanied by a per-lot Certificate of Analysis.
What is the difference between the 500 mg and 1000 mg vials?
The 500 mg and 1000 mg formats are analytically identical — same compound, same purity specification (≥99%), same lyophilization protocol, same packaging standard. They differ only in total NAD+ content per vial. Selection between the two is determined by the receiving laboratory's research workflow and material requirements.
Is NAD+ a peptide?
No. NAD+ is a coenzyme, specifically a pyridine nucleotide dinucleotide — not a peptide. It is composed of two nucleotides (one bearing adenine, one bearing nicotinamide) joined via phosphate groups, and is structurally and functionally distinct from peptide compounds. It is supplied within the DISSOLV LABS catalog as a research coenzyme reference compound.
What category does NAD+ belong to?
NAD+ is classified as a pyridine nucleotide coenzyme within the NAD+ metabolome family of research compounds. It is studied alongside its biosynthetic precursors NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside), and is one of the most extensively cited reference compounds in longevity, mitochondrial, sirtuin, and DNA-repair biology research.
How is NAD+ different from NMN and NR?
In published research literature, NMN and NR are described as biosynthetic precursors to NAD+. NR is converted intracellularly to NMN, which is then converted to NAD+. NAD+ itself is the final coenzyme form that serves as the direct substrate for sirtuin enzymes, PARP enzymes, and a wide range of redox reactions. Each occupies a distinct position within the NAD+ biosynthesis pathway studied in metabolism research.
What purity standard does DISSOLV LABS supply?
DISSOLV LABS supplies NAD+ at ≥99% purity, verified by reversed-phase HPLC, confirmed by mass spectrometry (HPLC-MS), and cross-checked by UV-Vis spectroscopy at the characteristic 260 nm absorbance. Each lot — in both vial formats — is accompanied by a Certificate of Analysis.
What analytical testing is performed on each lot?
Each NAD+ lot is subjected to RP-HPLC purity analysis, HPLC-MS identity confirmation, UV-Vis spectroscopic verification at 260 nm, residual solvent and moisture screening, and batch-consistency documentation. Third-party analytical verification is available upon institutional request.
How should NAD+ be stored?
Recommended storage is −20 °C, protected from light and moisture, in the original sealed vial. NAD+ is light-sensitive and hygroscopic; the amber vial and lyophilized format are designed to preserve coenzyme integrity. Refer to the lot-specific Certificate of Analysis for stability data.
How is NAD+ reconstituted for laboratory work?
NAD+ is typically reconstituted with sterile or bacteriostatic solvent in accordance with the receiving laboratory's internal protocols. Reconstituted NAD+ solutions are pH- and light-sensitive and should be handled according to standard laboratory practice. Reconstitution methodology is the responsibility of the qualified research professional.
Is NAD+ research use only?
Yes. NAD+ supplied by DISSOLV LABS is strictly for laboratory research use only. It is not intended for human or veterinary use, and is not intended to diagnose, treat, cure, or prevent any disease.
What compounds are related to NAD+?
NAD+ is commonly referenced alongside its biosynthetic precursors NMN and NR, its reduced form NADH, the precursor vitamer Niacinamide, sirtuin-pathway research compounds such as Resveratrol and Pterostilbene, and broader longevity research compounds including Epitalon and Spermidine.
Is a Certificate of Analysis (COA) available?
Yes. Every lot — in both 500 mg and 1000 mg formats — is shipped with a lot-specific Certificate of Analysis documenting purity, identity, spectroscopic verification, and analytical methodology. COAs are available to verified research accounts on request.
Who should handle NAD+?
NAD+ is intended exclusively for handling by qualified laboratory research professionals operating within appropriate research facilities. It is not for sale to or use by the general public.
Related Research Compounds
- NMN (Nicotinamide Mononucleotide) — direct biosynthetic precursor to NAD+
- NR (Nicotinamide Riboside) — upstream biosynthetic precursor research compound
- NADH — reduced form of NAD+; redox biology reference compound
- Niacinamide / Nicotinamide — vitamer precursor in the NAD+ biosynthesis pathway
- Resveratrol — polyphenol research compound studied in sirtuin-pathway research
- Pterostilbene — methylated stilbene analog of resveratrol
- Epitalon — synthetic tetrapeptide research compound studied in telomerase and longevity research
- Spermidine — polyamine research compound studied in autophagy and longevity research
Compliance
For laboratory research use only. This product is not intended for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease. Sale and distribution are restricted to qualified laboratory research professionals operating within appropriate research environments. The purchaser assumes full responsibility for safe handling, storage, and disposal in accordance with applicable institutional, local, and federal guidelines.
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