Description
What Is MOTS-c? (In Plain English)
MOTS-c is a tiny peptide whose recipe is written inside mitochondria — the little battery packs inside our cells — instead of in the cell's main instruction book. That is unusual, a bit like finding a note written by the battery rather than the phone. Scientists study MOTS-c in cells and in mice to learn how those batteries send messages to the rest of the cell.
MOTS-c — Research Overview
MOTS-c (Mitochondrial Open reading frame of the 12S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide, sequence MRWQEMGYIFYPRKLR, encoded within the mitochondrial genome rather than nuclear DNA. The literature associates it with activation of the AMPK energy-sensing pathway and with modulation of the folate–methionine one-carbon cycle, including AICAR accumulation as a proposed upstream step. It has also been reported to translocate to the nucleus under metabolic stress, where it is studied as a retrograde mitochondrial-to-nuclear signalling factor.
Primary Research Areas
- AMPK signalling — investigated in vitro for effects on the cellular energy-sensing cascade
- Metabolic regulation — studied in rodent models for glucose handling and insulin-sensitivity markers
- Mitochondrial retrograde signalling — examined for stress-induced nuclear translocation and gene-expression changes
- Exercise and skeletal muscle biology — referenced in the literature as a load-responsive mitochondrial peptide
- Aging models — circulating MOTS-c levels studied as a correlate in animal aging research
Specifications
- Compound: MOTS-c; Mitochondrial Open reading frame of the 12S rRNA type-c
- CAS: 1627580-64-6
- Presentation: Lyophilized powder, sealed vial
- Quantity: One lyophilized vial per unit; fill weight as stated in the listing options
- Storage: Store lyophilized vials cold and protected from light. Reconstituted material is stored refrigerated per standard laboratory practice.
Related Research Peptides
MOTS-c is usually studied next to Humanin 10 mg, the other well-characterised mitochondrial-derived peptide, and SS-31 10mg, a cardiolipin-targeting mitochondrial compound. Laboratories running broader cellular-energetics panels also stock NAD+ and Epithalon 10mg.
Why Researchers Source MOTS-c from Dissolv Labs
Dissolv Labs is a research-supply company based in Southern California. Orders are picked, packed, and shipped domestically from our SoCal facility, so most U.S. laboratories see short transit times and no international customs delay.
Every vial ships as a complete kit. Each MOTS-c vial is paired with its own bacteriostatic water reconstitution vial, so the material arrives ready to prepare in the lab without a separate diluent order. Compounds are supplied lyophilized in sealed, labeled vials with lot identification, and analytical documentation is available on request.
MOTS-c — Frequently Asked Questions
What is MOTS-c used for?
MOTS-c is supplied strictly as a research chemical for in vitro and laboratory research applications. The literature investigates it as a mitochondrial-derived peptide acting on AMPK and one-carbon metabolic pathways in cell and rodent models. It is not for human or veterinary use.
What makes MOTS-c different from a typical peptide?
Most research peptides correspond to nuclear-encoded proteins or synthetic analogues of them. MOTS-c is encoded inside the mitochondrial genome itself, which is why the literature places it in the small class of mitochondrial-derived peptides alongside humanin. That origin is the main reason it is studied as a retrograde signalling molecule.
How is MOTS-c prepared in the lab?
Vials arrive as sealed lyophilized powder with lot identification and are kept cold and out of light until use. Each kit includes a matched bacteriostatic water vial so reconstitution can be performed at the bench, and additional diluent is available as BAC Water 3ml. Reconstituted stock is refrigerated per standard laboratory practice.
Where can I buy MOTS-c research peptide?
MOTS-c is for sale directly from Dissolv Labs, shipped domestically from our Southern California facility to U.S. laboratories. Every order arrives as a complete kit with a matched reconstitution vial and lot-identified labeling. Purchases are limited to qualified researchers for Research Use Only applications.
Research Use Only
MOTS-c is sold exclusively as a Research Use Only (RUO) chemical. It is not a drug, supplement, cosmetic, or food, and it is not intended for human or veterinary use, ingestion, injection, topical application, or any form of consumption. It is intended solely for licensed laboratory research by qualified professionals. Dissolv Labs makes no medical, therapeutic, or diagnostic claims of any kind. By purchasing, the buyer confirms they are a qualified researcher and accepts full responsibility for lawful handling, use, and disposal.
Bacteriostatic (BAC) water is included free with every order.
Specifications
- Form: Lyophilized (freeze-dried) powder, sealed vial
- Appearance: White to off-white
- Purity: ≥99%, verified by HPLC
- Identity: Confirmed by mass spectrometry
- Testing: Independent third-party laboratory, every batch
- Documentation: Batch-specific COA available on request
Exact quantity and concentration are listed in the product title and variant options above. The figures above are release specifications — the measured result for your particular lot is stated on its Certificate of Analysis.
Documentation & Testing
Every batch is tested before release. Testing covers four checks: identity by mass spectrometry, purity by HPLC against a ≥99% release threshold, content verification against the labelled mass, and batch release tied to a specific lot number.
To request the Certificate of Analysis for your vial, email us with your order number or the lot number printed on the label. We do not gate documentation behind a form or a purchase.
New to reading a COA? Our plain-English guide decodes every line, and the full process is documented on our Quality & Testing page.
Handling & Storage
Lyophilized peptides are relatively stable during transit. Arriving at room temperature is not cause for concern — the cold pack is a margin of safety rather than a pass/fail condition.
Sealed vials of lyophilized material are typically stored refrigerated or frozen and protected from light. Handling protocols for a specific compound are determined by the researcher and their institution; we supply the material and its documentation.
Shipping & Returns
Orders placed before the daily cut-off are dispatched the same business day from Southern California in insulated packaging with ice packs. Tracking is issued at dispatch.
If a shipment arrives damaged, if vial contents appear inconsistent with the specification, or if the lot number on your vial does not match the certificate we provide, contact us and we will resolve it.
Because these are temperature-sensitive laboratory materials, opened vials cannot be returned to stock.
Questions
Straight answers about documentation, shipping, and what Research Use Only means.