MOTS-c — Mitochondrial-Derived Research Peptide

MOTS-c is a 16-amino-acid synthetic peptide referenced in scientific literature as a mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA. It is one of the most extensively profiled compounds within the emerging mitochondrial-nuclear signaling research category. DISSOLV LABS supplies MOTS-c as a 10 mg lyophilized vial — a high-purity analytical reference compound for qualified laboratory research professionals.

Purity: ≥99% (HPLC-MS verified)
Format: 10 mg lyophilized vial, sealed amber glass
Designation: Research use only — not intended for human or veterinary use

Compound Overview

MOTS-c (an acronym derived from Mitochondrial Open Reading frame of the Twelve S rRNA-c) is a short peptide encoded within the mitochondrial genome rather than the nuclear genome — a distinguishing characteristic that places it within the small but rapidly expanding family of mitochondrial-derived peptides. Within the published literature, MOTS-c is most commonly studied within AMPK pathway research, mitochondrial-nuclear signaling research, and metabolic homeostasis research models.

MOTS-c is frequently positioned alongside other mitochondrial-derived peptides such as Humanin and the SHLP family (Small Humanin-Like Peptides), and is studied in adjacency to mitochondrial-targeted research compounds including SS-31 (Elamipretide). It is a foundational reference compound in the broader mitochondrial biology and longevity research literature.

Research Context

MOTS-c has been investigated in published preclinical and clinical research and is commonly referenced in laboratory work involving:

• Mitochondrial-derived peptide (MDP) biology
• AMPK (AMP-activated protein kinase) pathway research
• Mitochondrial-nuclear retrograde signaling research
• Metabolic homeostasis and glucose metabolism research models
• Exercise physiology and muscle bioenergetics research
• Aging biology and longevity research domains
• Comparative mitochondrial peptide research (Humanin, SHLP family)
• Folate-cycle and methionine-cycle research models

Scientific Classification

Analytical & Quality Standards

Every MOTS-c lot supplied by DISSOLV LABS undergoes a structured analytical workflow designed to confirm identity, purity, and batch consistency before release.

• Purity verification by reversed-phase high-performance liquid chromatography (RP-HPLC)
• Identity confirmation by mass spectrometry (HPLC-MS)
• Residual solvent and moisture screening to documented thresholds
• Batch-to-batch consistency recorded on a per-lot Certificate of Analysis (COA)
• Third-party verification available upon institutional request
• Sterile lyophilization under inert conditions to preserve peptide integrity

Technical Specifications

Frequently Asked Questions

Related Research Compounds

• Humanin — mitochondrial-derived peptide research compound
• SHLP peptides — Small Humanin-Like Peptides (SHLP-1 through SHLP-6); mitochondrial-derived peptide family members
• SS-31 (Elamipretide) — mitochondrial-targeted research peptide
• NAD+ — pyridine nucleotide coenzyme; mitochondrial bioenergetics research
• NMN (Nicotinamide Mononucleotide) — NAD+ biosynthetic precursor research compound
• Epitalon — synthetic tetrapeptide research compound studied in telomerase and longevity research
• Spermidine — polyamine research compound studied in autophagy and longevity research

For laboratory research use only. This product is not intended for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease. Sale and distribution are restricted to qualified laboratory research professionals operating within appropriate research environments. The purchaser assumes full responsibility for safe handling, storage, and disposal in accordance with applicable institutional, local, and federal guidelines.

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