Description
What Is HGH Fragment 176-191 5mg? (In Plain English)
Growth hormone is a long chain of 191 building blocks, and this molecule is just the last little piece of it — blocks 176 through 191, snipped off like the tail end of a train. Because it is only the tail, it does not do everything the whole train does. Scientists study it to find out which jobs belong to that one small section.
HGH Fragment 176-191 5mg — Research Overview
HGH Fragment 176-191 is a synthetic 16-amino-acid peptide corresponding to the C-terminal region of human growth hormone, residues 176 to 191, and is the parent sequence from which the analogue AOD9604 is derived. The literature identifies this domain as the region associated with hGH's lipolytic activity in adipose tissue models, reported to proceed largely independently of growth hormone receptor-mediated JAK2/STAT5 signalling and of hepatic IGF-1 induction. Published in vitro and rodent work focuses on beta-adrenergic receptor involvement and hormone-sensitive lipase activity in adipocytes.
Primary Research Areas
- Adipocyte lipolysis — investigated in isolated adipocyte and 3T3-L1 culture systems.
- Structure-function mapping of hGH — used to separate lipolytic from somatogenic domains of the parent hormone.
- Lipogenesis inhibition — studied for effects on fatty-acid synthesis pathways in vitro.
- Metabolic animal models — examined in rodent studies of adipose tissue metabolism.
- Comparative fragment research — benchmarked against AOD9604 and full-length recombinant hGH.
Specifications
- Compound: HGH Fragment 176-191, hGH fragment, somatropin C-terminal fragment
- CAS: 66004-57-7
- Molecular formula: C78H125N23O23S2
- Molecular weight: 1817.09 g/mol
- Presentation: Lyophilized powder, sealed vial
- Quantity: 5mg per vial
- Storage: Store lyophilized vials cold and protected from light. Reconstituted material is stored refrigerated per standard laboratory practice.
Related Research Peptides
The closest comparator in the catalog is AOD9604 5mg, a stabilised analogue of this same fragment, alongside full-length HGH 191AA 24 IU as the parent-hormone reference. Metabolic panels often also include 5-Amino-1MQ 10mg and MOTS-c 10mg.
Why Researchers Source HGH Fragment 176-191 5mg from Dissolv Labs
Dissolv Labs is a research-supply company based in Southern California. Orders are picked, packed, and shipped domestically from our SoCal facility, so most U.S. laboratories see short transit times and no international customs delay.
Every vial ships as a complete kit. Each HGH Fragment 176-191 5mg vial is paired with its own bacteriostatic water reconstitution vial, so the material arrives ready to prepare in the lab without a separate diluent order. Compounds are supplied lyophilized in sealed, labeled vials with lot identification, and analytical documentation is available on request.
HGH Fragment 176-191 5mg — Frequently Asked Questions
What is HGH Fragment 176-191 5mg used for?
HGH Fragment 176-191 5mg is supplied strictly as a research chemical for in vitro and laboratory research applications. The literature studies it in adipocyte lipolysis and hGH structure-function research. It is not for human or veterinary use.
HGH Fragment 176-191 vs AOD9604 — what is the difference?
AOD9604 is the same C-terminal fragment carrying an added N-terminal tyrosine, a modification introduced to improve stability and handling. Investigators generally treat the two as closely related, and comparative studies use both to assess whether the modification alters in vitro activity.
Why does this fragment behave differently from full-length hGH?
The 176-191 region lacks the binding surfaces required for growth hormone receptor dimerisation, so the somatogenic and IGF-1-inducing arms of the parent hormone are largely absent in published models. That separation is precisely why the fragment is a useful research tool.
Where can I buy HGH Fragment 176-191 research peptide?
Dissolv Labs stocks HGH Fragment 176-191 5mg and ships it domestically from Southern California. Each order arrives as a complete kit with a BAC Water 3ml reconstitution vial, sealed and lot-labeled, with analytical documentation available on request.
Research Use Only
HGH Fragment 176-191 5mg is sold exclusively as a Research Use Only (RUO) chemical. It is not a drug, supplement, cosmetic, or food, and it is not intended for human or veterinary use, ingestion, injection, topical application, or any form of consumption. It is intended solely for licensed laboratory research by qualified professionals. Dissolv Labs makes no medical, therapeutic, or diagnostic claims of any kind. By purchasing, the buyer confirms they are a qualified researcher and accepts full responsibility for lawful handling, use, and disposal.
Bacteriostatic (BAC) water is included free with every order.
Specifications
- Form: Lyophilized (freeze-dried) powder, sealed vial
- Appearance: White to off-white
- Purity: ≥99%, verified by HPLC
- Identity: Confirmed by mass spectrometry
- Testing: Independent third-party laboratory, every batch
- Documentation: Batch-specific COA available on request
Exact quantity and concentration are listed in the product title and variant options above. The figures above are release specifications — the measured result for your particular lot is stated on its Certificate of Analysis.
Documentation & Testing
Every batch is tested before release. Testing covers four checks: identity by mass spectrometry, purity by HPLC against a ≥99% release threshold, content verification against the labelled mass, and batch release tied to a specific lot number.
To request the Certificate of Analysis for your vial, email us with your order number or the lot number printed on the label. We do not gate documentation behind a form or a purchase.
New to reading a COA? Our plain-English guide decodes every line, and the full process is documented on our Quality & Testing page.
Handling & Storage
Lyophilized peptides are relatively stable during transit. Arriving at room temperature is not cause for concern — the cold pack is a margin of safety rather than a pass/fail condition.
Sealed vials of lyophilized material are typically stored refrigerated or frozen and protected from light. Handling protocols for a specific compound are determined by the researcher and their institution; we supply the material and its documentation.
Shipping & Returns
Orders placed before the daily cut-off are dispatched the same business day from Southern California in insulated packaging with ice packs. Tracking is issued at dispatch.
If a shipment arrives damaged, if vial contents appear inconsistent with the specification, or if the lot number on your vial does not match the certificate we provide, contact us and we will resolve it.
Because these are temperature-sensitive laboratory materials, opened vials cannot be returned to stock.
Questions
Straight answers about documentation, shipping, and what Research Use Only means.