Description
What Is VIP? (In Plain English)
VIP stands for vasoactive intestinal peptide, a small natural chain of amino acids that nerve cells and gut cells make on their own. Think of it as a short note cells pass to each other that mostly says “ease off” — it shows up where blood vessels widen and where the immune system quiets down. Researchers study VIP in cell cultures and animal models to map which cells read that note and what they do next.
VIP — Research Overview
VIP is a 28-amino-acid neuropeptide belonging to the secretin/glucagon peptide superfamily, produced by neurons of the central and enteric nervous systems. The literature associates it with agonism at the class B G-protein-coupled receptors VPAC1 and VPAC2, with partial affinity also reported at the PAC1 receptor shared with PACAP. It is a long-established reference ligand in neuropeptide, circadian, and immunomodulation research.
Primary Research Areas
- VPAC receptor pharmacology — VPAC1/VPAC2 binding and cAMP signaling in receptor-expressing cell lines
- Circadian biology — VIP signaling between suprachiasmatic nucleus neurons in rodent and slice models
- Immune signaling research — cytokine profile studies in macrophage and T-cell cultures
- Smooth muscle and vascular studies — isolated tissue-bath work on vasodilatory and relaxant responses
- Enteric neuroscience — VIP-expressing neuron mapping in gastrointestinal tissue preparations
Specifications
- Compound: VIP (Vasoactive Intestinal Peptide, human sequence; VIP 1-28)
- CAS: 37221-79-7
- Molecular weight: ~3326.8 g/mol
- Presentation: Lyophilized powder, sealed vial
- Quantity: 5 mg per vial
- Storage: Store lyophilized vials cold and protected from light. Reconstituted material is stored refrigerated per standard laboratory practice.
Related Research Peptides
VIP is frequently studied alongside other peptides investigated in immune signaling and neuropeptide research. Related catalog items include Ara-290, KPV, TA-1, and PE-22-28.
Why Researchers Source VIP from Dissolv Labs
Dissolv Labs is a research-supply company based in Southern California. Orders are picked, packed, and shipped domestically from our SoCal facility, so most U.S. laboratories see short transit times and no international customs delay.
Every vial ships as a complete kit. Each VIP vial is paired with its own bacteriostatic water reconstitution vial, so the material arrives ready to prepare in the lab without a separate diluent order. Compounds are supplied lyophilized in sealed, labeled vials with lot identification, and analytical documentation is available on request.
VIP — Frequently Asked Questions
What is VIP used for?
VIP is supplied strictly as a research chemical for in vitro and laboratory research applications. The literature investigates it as a VPAC1/VPAC2 receptor agonist in neuropeptide signaling, circadian rhythm, and immune-modulation studies in cell and animal models. It is not for human or veterinary use.
How does VIP differ from PACAP?
VIP and PACAP are closely related members of the same peptide superfamily and share the VPAC1 and VPAC2 receptors. The main pharmacological distinction reported in the literature is at PAC1, where PACAP has far higher affinity than VIP. Laboratories use the pair to separate PAC1-dependent effects from shared VPAC signaling.
How is VIP handled in the laboratory?
VIP 5mg arrives as a lyophilized powder in a sealed, lot-labeled vial and is kept cold and shielded from light. Like most native neuropeptides it is sensitive to repeated freeze-thaw cycles, so reconstituted material is typically aliquoted and held refrigerated per standard laboratory practice. A BAC Water 3ml reconstitution vial ships with each order.
Where can I buy VIP research peptide?
VIP 5mg is available for sale from Dissolv Labs, a Southern California research-supply company shipping domestically across the United States. Every order ships as a complete kit with the reconstitution vial included. Analytical documentation is available on request for qualified laboratories.
Research Use Only
VIP is sold exclusively as a Research Use Only (RUO) chemical. It is not a drug, supplement, cosmetic, or food, and it is not intended for human or veterinary use, ingestion, injection, topical application, or any form of consumption. It is intended solely for licensed laboratory research by qualified professionals. Dissolv Labs makes no medical, therapeutic, or diagnostic claims of any kind. By purchasing, the buyer confirms they are a qualified researcher and accepts full responsibility for lawful handling, use, and disposal.
Bacteriostatic (BAC) water is included free with every order.
Specifications
- Form: Lyophilized (freeze-dried) powder, sealed vial
- Appearance: White to off-white
- Purity: ≥99%, verified by HPLC
- Identity: Confirmed by mass spectrometry
- Testing: Independent third-party laboratory, every batch
- Documentation: Batch-specific COA available on request
Exact quantity and concentration are listed in the product title and variant options above. The figures above are release specifications — the measured result for your particular lot is stated on its Certificate of Analysis.
Documentation & Testing
Every batch is tested before release. Testing covers four checks: identity by mass spectrometry, purity by HPLC against a ≥99% release threshold, content verification against the labelled mass, and batch release tied to a specific lot number.
To request the Certificate of Analysis for your vial, email us with your order number or the lot number printed on the label. We do not gate documentation behind a form or a purchase.
New to reading a COA? Our plain-English guide decodes every line, and the full process is documented on our Quality & Testing page.
Handling & Storage
Lyophilized peptides are relatively stable during transit. Arriving at room temperature is not cause for concern — the cold pack is a margin of safety rather than a pass/fail condition.
Sealed vials of lyophilized material are typically stored refrigerated or frozen and protected from light. Handling protocols for a specific compound are determined by the researcher and their institution; we supply the material and its documentation.
Shipping & Returns
Orders placed before the daily cut-off are dispatched the same business day from Southern California in insulated packaging with ice packs. Tracking is issued at dispatch.
If a shipment arrives damaged, if vial contents appear inconsistent with the specification, or if the lot number on your vial does not match the certificate we provide, contact us and we will resolve it.
Because these are temperature-sensitive laboratory materials, opened vials cannot be returned to stock.
Questions
Straight answers about documentation, shipping, and what Research Use Only means.