Description
GHK-Cu — Research Peptide
GHK-Cu is a naturally occurring copper-binding tripeptide referenced in the scientific literature as a complex of glycyl-L-histidyl-L-lysine chelated with divalent copper (Cu²⁺). It is one of the most extensively cited compounds within the dermal remodeling and extracellular matrix research peptide category. DISSOLV LABS supplies GHK-Cu as a 100 mg lyophilized vial — a high-purity analytical reference compound for qualified laboratory research professionals.
Purity: ≥99% (HPLC-MS verified)
Format: 100 mg lyophilized vial
Designation: Research use only — not intended for human or veterinary use
Compound Overview
GHK-Cu — the copper-bound form of the tripeptide GHK (Gly-His-Lys) — is a small molecule naturally present in human plasma, saliva, and urine, where it functions as a copper-transport ligand. Within the published literature, the GHK sequence is classified as a copper-binding signaling tripeptide, and the copper complex is studied as a reference compound for research involving extracellular matrix remodeling, dermal fibroblast pathway models, and gene expression profiling.
GHK-Cu is structurally and mechanistically distinct from larger regenerative peptides such as BPC-157 and TB-500, and from α-MSH-derived fragments such as KPV. It occupies a unique position within the Recovery research peptide category as the principal copper peptide reference standard.
Research Context
GHK-Cu has been investigated in an extensive body of preclinical research and is commonly referenced in laboratory work involving:
- Extracellular matrix and collagen pathway research
- Dermal fibroblast signaling models
- Copper-transport and chelation chemistry research
- Gene expression profiling and transcriptomic studies
- Hair follicle and dermal papilla pathway research
- Angiogenesis and vascular endothelial signaling research
- Comparative tripeptide structure–activity profiling
Scientific Classification
| Compound name | GHK-Cu |
| Alternative designations | Copper Tripeptide-1 · Glycyl-L-Histidyl-L-Lysine Copper Complex · Cu-GHK · GHK-Copper |
| Molecular class | Copper-binding tripeptide complex |
| Amino acid sequence | Glycine – Histidine – Lysine (Gly-His-Lys) |
| Functional category | Dermal remodeling and extracellular matrix research peptide |
| Peptide family | Copper-binding signaling tripeptides |
| Research domains | Extracellular matrix biology, dermal fibroblast research, copper chelation chemistry, gene expression profiling, regenerative pathway research |
| Adjacent compounds | BPC-157, TB-500, BPC-157 / TB-500 research stack, KPV |
Analytical & Quality Standards
Every GHK-Cu lot supplied by DISSOLV LABS undergoes a structured analytical workflow designed to confirm identity, purity, copper coordination, and batch consistency before release.
- Purity verification by reversed-phase high-performance liquid chromatography (RP-HPLC)
- Identity confirmation by mass spectrometry (HPLC-MS)
- Copper coordination verification consistent with the GHK-Cu²⁺ complex
- Residual solvent and moisture screening to documented thresholds
- Batch-to-batch consistency recorded on a per-lot Certificate of Analysis (COA)
- Third-party verification available upon institutional request
- Sterile lyophilization under inert conditions to preserve peptide integrity
Technical Specifications
| Format | 100 mg lyophilized vial |
| Appearance | Characteristic blue lyophilized solid (reflecting Cu²⁺ coordination) |
| Packaging | Sealed amber glass vial, crimped seal |
| Catalog identifier | DSL-GHK-100 |
| Purity | ≥99% (HPLC-MS verified) |
| Recommended storage | −20 °C, protected from light and moisture |
| Reconstitution | Sterile or bacteriostatic solvent (laboratory protocol only) |
| Stability | Stable under recommended storage conditions; refer to lot COA |
| Handling | Restricted to qualified research personnel |
Frequently Asked Questions
What is GHK-Cu?
GHK-Cu is a naturally occurring copper-binding tripeptide complex referenced in scientific literature as the chelated form of glycyl-L-histidyl-L-lysine (GHK) with divalent copper (Cu²⁺). It is one of the most extensively studied compounds within the dermal remodeling and extracellular matrix research peptide category. Supplied by DISSOLV LABS as an analytical reference compound for laboratory research use only.
What does GHK-Cu stand for?
GHK refers to the tripeptide sequence Glycine–Histidine–Lysine. The "Cu" designates that the tripeptide is complexed with divalent copper (Cu²⁺). It is also referenced in the literature as Copper Tripeptide-1, Cu-GHK, or the glycyl-L-histidyl-L-lysine copper complex.
What is the amino acid sequence of GHK-Cu?
The peptide backbone is composed of three amino acids in sequence: glycine, histidine, and lysine (Gly-His-Lys). The histidine and lysine residues, along with the N-terminal glycine, coordinate the copper (II) ion to form the characteristic GHK-Cu complex.
What vial size is available?
DISSOLV LABS supplies GHK-Cu as a 100 mg lyophilized vial (catalog DSL-GHK-100), produced from ≥99% purity reference material and accompanied by a per-lot Certificate of Analysis.
Why is the powder blue?
The characteristic blue color of GHK-Cu in lyophilized form reflects the coordination of divalent copper (Cu²⁺) by the tripeptide ligand. This visual indicator is consistent with proper copper complexation, and is a recognized feature of GHK-Cu as a reference standard.
What category does GHK-Cu belong to?
GHK-Cu is classified within the copper-binding signaling tripeptide family and is studied as the principal copper peptide reference compound within the broader Recovery research peptide category. It is referenced alongside BPC-157, TB-500, and KPV in regenerative pathway research literature.
How does GHK-Cu differ from BPC-157 and TB-500?
In published research literature, GHK-Cu is described as a copper-binding tripeptide studied in dermal fibroblast and extracellular matrix research; BPC-157 is a body protection compound-derived pentadecapeptide studied in connective tissue and gastrointestinal pathway research; and TB-500 is a Thymosin Beta-4 active fragment studied in actin-binding and cellular migration research. Each compound occupies a distinct position within the broader Recovery research peptide category.
How does GHK-Cu differ from KPV?
GHK-Cu and KPV are both small peptides studied within the Recovery research category, but they are structurally and mechanistically distinct. GHK-Cu is a copper-binding tripeptide (Gly-His-Lys + Cu²⁺) studied in extracellular matrix and dermal remodeling research, while KPV is an α-MSH-derived tripeptide (Lys-Pro-Val) studied in inflammatory signaling research.
What purity standard does DISSOLV LABS supply?
DISSOLV LABS supplies GHK-Cu at ≥99% purity, verified by reversed-phase HPLC and confirmed by mass spectrometry (HPLC-MS). Copper coordination is verified consistent with the GHK-Cu²⁺ complex. Each lot is accompanied by a Certificate of Analysis.
What analytical testing is performed on each lot?
Each GHK-Cu lot is subjected to RP-HPLC purity analysis, HPLC-MS identity confirmation, copper coordination verification, residual solvent and moisture screening, and batch-consistency documentation. Third-party analytical verification is available upon institutional request.
How should GHK-Cu be stored?
Recommended storage is −20 °C, protected from light and moisture, in the original sealed vial. Refer to the lot-specific Certificate of Analysis for stability data.
How is GHK-Cu reconstituted for laboratory work?
GHK-Cu is typically reconstituted with sterile or bacteriostatic solvent in accordance with the receiving laboratory's internal protocols. Reconstitution methodology is the responsibility of the qualified research professional.
Is GHK-Cu research use only?
Yes. GHK-Cu supplied by DISSOLV LABS is strictly for laboratory research use only. It is not intended for human or veterinary use, and is not intended to diagnose, treat, cure, or prevent any disease.
What compounds are related to GHK-Cu?
GHK-Cu is commonly referenced alongside BPC-157, TB-500, BPC-157 / TB-500 combination research stacks, and KPV — all of which are studied within tissue repair, regenerative pathway, and connective tissue research domains.
Is a Certificate of Analysis (COA) available?
Yes. Every lot is shipped with a lot-specific Certificate of Analysis documenting purity, identity, copper coordination, and analytical methodology. COAs are available to verified research accounts on request.
Who should handle GHK-Cu?
GHK-Cu is intended exclusively for handling by qualified laboratory research professionals operating within appropriate research facilities. It is not for sale to or use by the general public.
Related Research Compounds
- BPC-157 — body protection compound-derived pentadecapeptide research peptide
- TB-500 — Thymosin Beta-4 active fragment research peptide
- BPC-157 / TB-500 Research Stack — combination research preparation pairing BPC-157 with TB-500
- KPV — α-MSH-derived tripeptide research compound (lysine-proline-valine)
Compliance
For laboratory research use only. This product is not intended for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease. Sale and distribution are restricted to qualified laboratory research professionals operating within appropriate research environments. The purchaser assumes full responsibility for safe handling, storage, and disposal in accordance with applicable institutional, local, and federal guidelines.
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